Much is said about the incidence of creatine for the kidneys, wrongly pointing out that this nutritional supplement damages them. This isn't true, but it doesn't mean that precautions shouldn't be taken in some cases.
Currently, many people have doubts about whether creatine is safe for the kidneys or not. That’s because there’s a lot of information circulating that claims that it causes damage to these organs. This is basically a myth, but it doesn’t mean that we shouldn’t take precautions.
Let’s remember that creatine is considered one of the most effective dietary supplements, capable of contributing to increased strength and muscle mass. It also promotes performance in high-intensity exercise. Despite this, there’s also been talk of the supposed harmful effects of creatine on the kidneys.
Frequent exercisers, especially strength trainers, often have a high-protein diet and use creatine as a supplement. Some have suspected that this could place an excessive burden on the kidneys. So, the key question is: Is creatine safe for the kidneys? Let’s see.
What’s creatine?
In principle, creatine’s a molecule that’s naturally present in the body. It’s created from some amino acids that are inside proteins. Likewise, we obtain creatine from foods such as fish and meat.
Most of the creatine we have is stored in the muscles and that’s where it performs its main functions. The body produces more or less half of the creatine we need daily. So, we have to acquire the rest through food.
That’s why we have creatine in the form of a nutritional supplement, which is mainly used by athletes to improve performance. This supplement allows them to increase strength, power, endurance, and recovery capacity. It’s not considered a doping substance.
Creatine’s a naturally occurring substance, but tends to be consumed artificially as a supplement.
The uses and side effects of creatine
Several investigations have been carried out to establish the effects that creatine, as a nutritional supplement, has on the body. These studies indicate that the main effects of this substance are the following:
Increased physical performance: It basically increases energy levels and is efficient for sprinters and weightlifters. There are conclusive studies that show that supplementation with this substance increases the athlete’s strength.
Improvement of rare deficiency syndromes: Some children have rare syndromes that are characterized by creatine deficiency in their bodies. The supplement helps to reduce some symptoms.
Stopping skin aging: Studies indicate that creatine in creams helps to reduce the signs of aging in the skin, mainly in the case of men.
If creatine supplementation is used properly, it doesn’t produce harmful effects. However, there may be negative effects of creatine on the kidneys in those who have previous kidney problems.
Likewise, high doses of this supplement, in some cases, cause side effects, such as:
Nausea and dizziness
Cramps
Dehydration and fluid retention
Fever and heat intolerance
Find out more: Dietary Supplements to Promote Well-Being
Is creatine safe for the kidneys?
Going back to the question of whether creatine is safe for the kidneys, there are at least 12 studies that address this aspect. All of them conclude that this nutritional supplement doesn’t cause any negative effects on the kidneys of healthy adults.
Nor does it cause harmful renal effects in those suffering from ALS (amyotrophic lateral sclerosis), type 2 diabetes, or in menopausal or postmenopausal women. Despite this, experts recommend caution regarding its consumption in some specific cases.
This warning, as we mentioned above, applies mainly to those who have kidney problems or are at high risk of suffering from them. In particular, if they consume protein in excess. In fact, there’s evidence that excess protein intake, even without creatine intake, accelerates damage in those with kidney problems.
Many use creatine as a protein supplement, and excess protein can affect the kidneys of people who already have a previous kidney disorder.
Continue reading: Nutrition and Kidney Failure: Everything You Need to Know
A myth that has spread
There are a large number of publications that state that creatine is always harmful to the kidneys. However, these statements are based on some incorrect information that has spread without real evidence.
Creatine increases the creatinine level in the body, but it does so independently of renal function. However, creatinine level is an indicator of kidney damage, and if someone frequently ingests creatine, it will appear elevated in urine tests, without necessarily being a sign of kidney problems.
Also, the supplement generates fluid retention, and therefore, it’s always important for hydration to be more frequent when taking creatine. But this doesn’t mean that creatine is unsafe for the kidneys.
All cited sources were thoroughly reviewed by our team to ensure their quality, reliability, currency, and validity. The bibliography of this article was considered reliable and of academic or scientific accuracy.
Antonio, J., Candow, D. G., Forbes, S. C., Gualano, B., Jagim, A. R., Kreider, R. B., … & Ziegenfuss, T. N. (2021). Common questions and misconceptions about creatine supplementation: what does the scientific evidence really show?. Journal of the International Society of Sports Nutrition, 18, 1-17. https://link.springer.com/article/10.1186/s12970-021-00412-w#Sec1
Clarke, Holly, et al. “The evolving applications of creatine supplementation: could creatine improve vascular health?.” Nutrients 12.9 (2020): 2834. https://www.mdpi.com/2072-6643/12/9/2834
de Silva, A. D. S., Pertille, A., Barbosa, C. G. R., de Oliveira Silva, J. A., de Jesus, D. V., Ribeiro, A. G. S. V., … & de Oliveira, J. J. (2019). Effects of creatine supplementation on renal function: a systematic review and meta-analysis. Journal of Renal Nutrition, 29(6), 480-489. https://www.sciencedirect.com/science/article/pii/S1051227619302286
do Vale BarachoI, N. C., de CastroII, L. P., da Cunha BorgesII, N., & LairaII, P. B. (2015). Study of renal and hepatic toxicity in rats supplemented with creatine1. Acta Cirúrgica Brasileira, 30(5). https://pubmed.ncbi.nlm.nih.gov/26016930/
Gualano, B., de Salles Painelli, V., Roschel, H., Lugaresi, R., Dorea, E., Artioli, G. G., … & Lancha Junior, A. H. (2011). Creatine supplementation does not impair kidney function in type 2 diabetic patients: a randomized, double-blind, placebo-controlled, clinical trial. European J0urnal of Applied Physiology, 111, 749-756. https://link.springer.com/article/10.1007/s00421-010-1676-3
Kreider, R. B., Kalman, D. S., Antonio, J., Ziegenfuss, T. N., Wildman, R., Collins, R., … & Lopez, H. L. (2017). International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine. Journal of the International Society of Sports Nutrition, 14(1), 18. https://www.tandfonline.com/doi/full/10.1186/s12970-017-0173-z
Poortmans, J. R., Auquier, H., Renaut, V., Durussel, A., Saugy, M., & Brisson, G. R. (1997). Effect of short-term creatine supplementation on renal responses in men. European Journal of Applied Physiology and Occupational Physiology, 76, 566-567. https://link.springer.com/article/10.1007/s004210050291
Schröder, H., Terrados, N., & Tramullas, A. (2005). Risk assessment of the potential side effects of long–term creatine supplementation in team sport athletes. European Journal of Nutrition, 44, 255-261. https://link.springer.com/article/10.1007/s00394-004-0519-6
Thorsteinsdottir, B., Grande, J. P., & Garovic, V. D. (2006). Acute renal failure in a young weight lifter taking multiple food supplements, including creatine monohydrate. Journal of Renal Nutrition, 16(4), 341-345. https://pubmed.ncbi.nlm.nih.gov/17046619/
Wallimann, T., Tokarska-Schlattner, M., & Schlattner, U. (2011). The creatine kinase system and pleiotropic effects of creatine. Amino Acids, 40, 1271-1296. https://pubmed.ncbi.nlm.nih.gov/21448658/
This text is provided for informational purposes only and does not replace consultation with a professional. If in doubt, consult your specialist.
