The Uses and Side Effects of Zaldiar

Zaldiar is a drug that is composed of two analgesic active ingredients but with different mechanisms of action. Keep reading to discover the uses and side effects of Zaldiar.
The Uses and Side Effects of Zaldiar
María Vijande

Reviewed and approved by the pharmacist María Vijande.

Written by María Vijande

Last update: 27 May, 2022

In the article below, we want to tell you all about the uses and side effects of Zaldiar.

Zaldiar is the brand name of a drug containing two active ingredients: tramadol and acetaminophen. These two substances have analgesic effects, so doctors prescribe Zaldiar mainly for the treatment of pain or, in other words, as a painkiller.

Specifically, it’s useful in the symptomatic treatment of moderate to severe pain, whenever the physician believes that the combination of tramadol and paracetamol is necessary. The dose of acetaminophen is 325 milligrams and the dose of tramadol is 37.5 milligrams.

Patients over the age of 12 can take this drug. And, as for the dosage, the physician will adjust it according to the patient’s characteristics. However, it should never exceed 8 tablets per day with an interval between doses of 6 hours.

Also, it can produce physical and psychological dependence and tolerance. Therefore, following the guidelines that the physician establishes is essential.

What is paracetamol?

The chemical composition of acetaminophen, also known as paracetamol.

an analgesic and antipyretic drug that belongs to the NSAID family

Due to these properties, doctors prescribe it for the treatment of mild and moderate pain and to treat febrile states. Patients usually take it orally, although it’s available for rectal and intravenous administration as well.

To achieve these effects, experts believe that paracetamol inhibits a variant of the COX enzyme found only in the brain: COX-3. It’s for this reason that it has no anti-inflammatory effects. However, experts are not certain as to the mechanism of action of this drug.

COX enzymes are responsible for the synthesis of thromboxanes and prostaglandins, substances responsible for fever and pain. Therefore, due to their inhibition, these pathological processes will improve.

What about tramadol?

Tramadol is another analgesic drug but it belongs to the opioid analgesic family. Therefore, it doesn’t reduce pain but affects the perception of this symptom.

This is true both at the site of the lesion and in the central and peripheral nervous system. To achieve this effect, tramadol affects the transmission and intensity of the pain signal.

The administration of this drug is also oral. The WHO analgesic ladder places it in the second step, while paracetamol is on the first step. Healthcare professionals use this ladder widely as a guide for pain management.

Find out more: Tramadol: What Is it and What’s it Used For?

The side effects of Zaldiar

A woman leaning over a toilet and looking nauseous because of the effects of zaldiar
Nausea can also appear as a consequence of an intestinal infection or heavy digestions.

Like all drugs on the market, Zaldiar can cause several adverse effects. We understand adverse effects as all those undesirable and unintentional events that occur and can be expected in the treatment with a drug.

In this sense, among the adverse side effects of Zaldiar that occur most frequently and that have been collected in clinical trials, we can mention:

  • Flatulence
  • Nausea and vomiting
  • Dry mouth
  • Headache
  • Gastrointestinal problems, such as constipation or diarrhea

Also, as we mentioned at the beginning of the article, Zaldiar can cause dependence and tolerance due to the effects of tramadol, since it’s an opioid drug. These effects can develop at the doses that the physician prescribes.

It’s for this reason that patients who take this analgesic drug require regular monitoring to avoid a loss of pharmacological efficacy. Also, people who’ve already abused drugs or who’ve suffered from another dependency should be particularly cautious.

On the other hand, to avoid health complications, when the patient has to stop taking Zaldiar, they should do so progressively. This is because an abrupt interruption of this type of drug can trigger withdrawal syndrome.

What to keep in mind about the effects of Zaldiar

A doctor handing medication to a patient.

Because of the positive effects of Zaldiar, it’s widely used to combat episodes of pain. However, this drug shouldn’t be abused, as it can cause dependence and tolerance, so doses should be reviewed periodically.

You can ask your doctor any questions you may have about this drug, as well as tell them about any new symptoms you may have since you started treatment with it.

  • Dhillon, S. (2010). Tramadol/paracetamol fixed-dose combination: A review of its use in the management of moderate to severe pain. Clinical Drug Investigation.
  • Altun, D., Çınar, Ö., Özker, E., & Türköz, A. (2017). The effect of tramadol plus paracetamol on consumption of morphine after coronary artery bypass grafting. Journal of Clinical Anesthesia.
  • Serrie, A., Ganry, H., Creuzé, A., & Schatz, B. (2011). Epidemiological data, efficacy and safety on a fixed combination of paracetamol (325mg) and tramadol (37.5mg) in the treatment of moderate to severe pain, in general practice (ELZA survey: Efficacite et to lerance de ZAldiar®). Journal of Applied Therapeutic Research.

The contents of this publication are for informational purposes only. At no time can they serve to facilitate or replace the diagnoses, treatments, or recommendations of a professional. Consult with your trusted specialist if you have any doubts and seek their approval before beginning any procedure.