The Effects of Aceclofenac

Aceclofenac is a nonsteroidal anti-inflammatory drug (NSAID) used primarily to treat pain episodes caused by rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis.
The Effects of Aceclofenac

Last update: 16 December, 2019

Aceclofenac is a nonsteroidal anti-inflammatory drug, or NSAID, widely used for pain and inflammation relief associated with rheumatic diseases. It has analgesic, anti-inflammatory, and anti-rheumatic effects. We’ll look at the effects of aceclofenac in this article.

Chemically speaking, it’s an acetic acid derivative. It has a similar structure to another analgesic drug, diclofenac.

Doctors prescribe this drug in cases where a patient needs treatment for inflammatory and painful conditions such as low back pain, toothache, and joint pain.

Also, doctors prescribe it to treat chronic pain and inflammation associated with chronic joint processes: osteoarthritis, rheumatoid arthritis, and spondylitis.

What’s rheumatoid arthritis?

Rheumatoid arthritis of the knee.

Rheumatoid arthritis is a chronic inflammatory autoimmune disease. This disease affects multiple joints and has various general and nonspecific symptoms.

If you don’t treat this condition properly, it can cause significant physical limitations, significantly worsening the patient’s quality of life.

In terms of symptoms, rheumatoid arthritis typically manifests with pain and stiffness, and also difficulty moving different small and large joints.

General symptoms, which sometimes precede articular manifestations, and tend to persist throughout the progression of the disease, include, among others:

  • Fatigue
  • Slight fever
  • Ill feeling
  • Loss of appetite
  • Weight loss

However, the most common symptom is morning stiffness, especially in the feet and hands.

The triggers of rheumatoid arthritis are still unknown. However, as we mentioned above, we know that it’s an autoimmune disorder and that other causes and genetic and non-genetic factors lead to its manifestation.


Doctors recommend aceclofenac for this condition, too. Osteoarthritis is another rheumatic disease that damages joint cartilage.

The joints contain a fluid known as synovial fluid that the synovial membrane produces. The ends of the bones that come together to form a joint are covered with articular cartilage.

When this cartilage experiences damage, it causes pain, stiffness, and functional disability. It is, therefore, important to differentiate this disease from arthritis. The latter develops due to joint inflammation, not cartilage wear.

However, since they both cause pain, aceclofenac is effective for the treatment of the symptoms they both cause.

Ankylosing spondylitis

Ankylosing spondylitis.

Ankylosing spondylitis is another rheumatic disease that causes inflammation of the spine and sacroiliac joints. Although the exact cause of this condition is unknown, some experts have linked it, in specific cases, to genetic inheritance.

It usually manifests in adolescence or young adulthood and its incidence is higher in men. By contrast, women may manifest a milder form of the disease, which makes it harder to diagnose.

Usually, it manifests with low back pain episodes that can affect the entire spine and peripheral joints, causing pain in both, as well as spinal stiffness, loss of mobility, and progressive joint deformity.

The effects of aceclofenac

A doctor holding pills.

The anti-inflammatory effects of aceclofenac can result from prostaglandin synthesis inhibition by the inhibition of the cyclo-oxygenase (COX) enzyme.

Prostaglandins are protein structures that play a role in many bodily processes, such as pain sensation. Thus, by inhibiting its synthesis, pain sensation decreases.

Aceclofenac also has an antipyretic effect, which may be due to peripheral vasodilation caused by a central action on the hypothalamus. There are also other effects caused by prostaglandin synthesis inhibition:

  • Decreased protection of the gastric mucosa. Aceclofenac can cause gastric ulcers.
  • Impaired kidney function.
  • Inhibition of platelet aggregation.


Aceclofenac is a nonsteroidal anti-inflammatory drug (NSAID) used primarily to treat pain episodes caused by rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis.

However, like other drugs, it has a number of adverse reactions that should be controlled, such as gastrointestinal disturbances and occasional dizziness. Therefore, you should talk to your doctor or pharmacist if you have any questions about this drug.

It might interest you...
What Is Dexketoprofen Used For?
Step To HealthRead it in Step To Health
What Is Dexketoprofen Used For?

Dexketoprofen is an NSAID that's widely used to relieve many types of pains. In this article, you'll discover its uses and precautions.

  • Chandrasekharan, N. V. (2011). Aceclofenac. In xPharm: The Comprehensive Pharmacology Reference.
  • Brogden, R. N., & Wiseman, L. R. (1996). Aceclofenac : A Review of its Pharmacodynamic Properties and Therapeutic Potential in the Treatment of Rheumatic Disorders and in Pain Management. Drugs Drugs.
  • Legrand, E. (2004). Aceclofenac in the management of inflammatory pain. Expert Opinion on Pharmacotherapy.