Scientists May Have Found a Possible Source of Depression

What if the probability of suffering from depression were determined by internal factors?  According to a recent study, it's possible that there are different cerebral connections that cause this condition. This may be the physical source of depression.
Scientists May Have Found a Possible Source of Depression

Last update: 24 April, 2019

A scientific advance may have found a possible physical source of depression in the brain. The discovery may give rise to theories that change the treatment and perception of mental illness. This would be a big step in the understanding of the physical cause of depression.

The University of Warwick in the UK and the University of Fudan in China have demonstrated that depression affects the orbital frontal lateral cortex of the brain.

This part of the brain is activated when suffering punishment or when it does not receive rewards.  Because of this, it is thought that depression may be associated with the feeling a person gets when not being rewarded.

Studying the Sources of Depression


Professor Feng, author of the study, said:

“At least one out of ten people suffer from depression throughout their lives. Depression is an illness that is so common in modern society that we can even find traces of Prozac (an anti-depressant) in the tap water in London.”

“Our discovery, with the combination of much data through out the world and our new methods, allows us to locate the source of depression.

This should open new paths for better therapeutic treatments in the near future and therefore enable us to treat this terrible illness.”

Results of the Study

the source of depression

Researchers obtained important conclusions after scanning the brains of 909 people in China using high-precision MRIs.

This technique showed the activity of the connections between the different parts of the human brain affected by depression. This included the orbital frontal media cortex and lateral.

The orbital frontal lateral, which is associated with lack of rewards, showed a stronger connectivity in the depressed group of subjects.

These discoveries regarding the connection between depression and these connections in the orbital frontal cortex will be very useful for developing better treatments.

The Source of Depression

This important study has demonstrated that this part of the brain, the orbital frontal cortex, is activated when a person suffers severe punishment or when a desired reward is not received.

Because of this, experts believe that depression may be associated with these perceptions.

The discovery may enable us to try new ways to treat and perceive this mental condition. At the same time, this provides important steps to understanding the physical cause of depression.

Other Factors that Have an Impact on Depression

source of depression

There’s no one thing that causes depression. In reality, some people are more prone to having depression than others, and there are a wide variety of possible causes and risk factors.

Therefore, there are various possible causes that attempt to explain this predisposition:

Genetic and Biochemical Factors

  • Heredity. There is a major risk of suffering from clinical depression when there is a family history of the illness. Because of this, scientists claim that there is a biological predisposition.
  • Biochemical factors. In addition, studies show that the biochemistry of the brain plays a very important role in depression. People with severe depression tend to have an imbalance of certain chemical substances in the brain, known as neurotransmitters.
  •  It is also true that sleep patterns tend to be different in people who have depression.
  • Finally, certain medications can cause or alleviate depression and certain hormones can alter emotional states.

Environmental factors as a Possible Source of Depression

  • In addition, difficult life situations such as the death of a close family member or a friend can be the cause.  A chronic illness, interpersonal problems, economical problems, a divorce (etc.) may also cause depression. If sustained for a period of time, this can end up in clinical depression.
  • Seasonal Affective Disorder (SAD).  There are individuals who develop depression during the winter months when days are shorter. This is commonly called Seasonal Affective Disorder. It may be that a decrease in hours of light affects the balance of certain chemical compounds in the brain. This can cause depression in some people.
  • Personality. People who have negative mental images, low self-esteem, the feeling of lack of control over circumstances in their life and a tendency to worry excessively are more apt to suffer from depression. It seems that a pattern of negative thoughts tends to establish itself  in childhood or adolescence. After a time, this may result in a depressed personality.

If you or a loved one suffers from depression, never hesitate to get some help. It’s the best way to recover and feel great again!

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