Presentation and Uses of Rosuvastatin

Rosuvastatin is a drug used to lower cholesterol levels and prevent the progression of atherosclerosis in adults. Here, we'll tell you more.
Presentation and Uses of Rosuvastatin

Last update: 06 January, 2021

Rosuvastatin is a drug that belongs to a group of drugs called statins. It helps to reduce both total cholesterol levels and LDL cholesterol. In addition, it helps prevent cardiovascular issues.

In addition, it can slow the progression of atherosclerosis in adultsThis can prevent and reduce the risk of heart attack, stroke and other heart diseases.

How does Rosuvastatin work?

Cholesterol in the blood.

In the blood, we have bad cholesterol (LDL) and good cholesterol (HDL). Rosuvastatin works by lowering bad cholesterol levels and increasing good cholesterol levels. To do this, Rosuvastatin blocks the production of bad cholesterol and improves the body’s ability to remove it from the blood.

If you don’t treat high cholesterol levels, fatty deposits can form on the walls of blood vessels, leading to atherosclerosis.

Atherosclerosis is a disease that causes a narrowing of the arteries. Then, they can become blocked and prevent blood from reaching the heart or brain normally.

Treatment with Rosuvastatin lowers cholesterol levels and, as a result, reduces the risk of cardiovascular problems. However, even if you achieve the correct cholesterol levels, you shouldn’t stop treatment. Rosuvastatin stops cholesterol levels from rising again.

How to take Rosuvastatin

To take Rosuvastatin, you need to follow your doctor’s instructions. You can take this medicine at any time of day, with or without food. Usually, the starting dose for adults with high cholesterol levels is 5 mg or 10 mg.

The dose will depend on cholesterol levels, as well as the cardiovascular risk you have. However, the doctor will start treatment with 5 mg in the following cases:

  • If you’re of Asian origin
  • Over 70 years old
  • If you have kidney problems
  • Risk of muscle cramps

If necessary, your doctor can double the dose to 20 mg, then 40 mg, with an interval of four weeks between each dose adjustment.

The maximum daily dose of Rosuvastatin is 40 mg. It’s only used for patients with high cholesterol levels and a high cardiovascular risk who can’t reduce levels with the 20 mg dose.

However, the starting dose of Rosuvastatin to lower the risk of heart attack, stroke or cardiovascular health problems is 20 mg per day. It’s important to check your cholesterol on a regular basis to see if it has normalized and is at an appropriate level.

Possible side effects

A person taking a pill with water.

Rosuvastatin can cause side effects, like all medicines. However, not everyone gets them. Usually, they’re mild and disappear after a short time.

You’ll need to stop taking this medicine if you have an allergic reaction. For example, if you suffer difficulty breathing, severe itchy skin, and swelling of the face, lips, tongue or throat.

In addition, consult your doctor if you suffer pain and muscle cramping that last longer than usual. Muscle symptoms are more common in children and teens than in adults.

Common adverse side effects include headache and stomach pain, constipation, nausea, muscle pain, and general weakness. As for the less common side effects, they are skin reactions and increased protein in urine with daily doses of 5 mg, 10 mg and 20 mg. 

The rare side effects that Rosuvastatin patients may experience are:

  • Severe allergic reactions
  • Muscle injuries
  • Severe stomach pain
  • Increased transaminases
  • Jaundice and hepatitis
  • Tendon injury
  • Memory loss
  • Injury to the nerves of the legs and arms, with numbness

Usually, patients tolerate Rosuvastatin treatment well. However, it can sometimes have severe side effects and adverse effects like myalgia, myopathy, and elevated serum transaminases.

Additionally, there’s a significant percentage of patients who use statins, but then have to stop taking them. This is due to their side effects, particularly myalgia.


Rosuvastatin is the most effective statin available today for lowering total and LDL cholesterol. Also, it’s been shown to be effective in the treatment of atherosclerotic plaques in the coronary and carotid arteries.

It might interest you...
How to Keep Your Arteries Healthy
Step To Health
Read it in Step To Health
How to Keep Your Arteries Healthy

Being physically active and consuming more omega 3 fatty acids are two ways to protect your arteries and keep your arteries healthy. Start today!

  • Domingos, H., Cunha, R. V. da, Paniago, A. M. M., Souza, A. S. de, Rodrigues, R. L., & Domingos, J. A. (2012). Rosuvastatina e ciprofibrato no tratamento da dislipidemia em pacientes com HIV. Arquivos Brasileiros de Cardiologia.×2012005000096
  • Bottaro, E. G., Caravello, Ó., Scapellato, P. G., Stambulian, M., Vidal, G. I., Loggia, V., … Cassetti, I. (2008). Rosuvastatina para tratamiento de la dislipidemia en pacientes infectados con VIH en tratamiento antirretroviral de gran actividad. Experiencia preliminar. Enfermedades Infecciosas y Microbiologia Clinica.
  • Gómez-García, A., Torres, G. M., Ortega-Pierres, L. E., Rodríguez-Ayala, E., & Álvarez-Aguilar, C. (2007). Rosuvastatina y metformina reducen la inflamación y el estrés oxidativo en pacientes con hipertensión y dislipemia. Revista Espanola de Cardiologia.