Scientists Discover A New and Effective Enzyme to Treat Migraines

March 18, 2019
A high percentage of the population suffers from headaches. Statistics show it primarily affects women. This evident reality pushes scientists to search for new advances and treatments each year in hopes of alleviating or even eliminating the frightening suffering caused by migraines.

According to a recent study by the International Society of DAO Deficiency and the Cataluña’s General Hospital, they may be able to treat migraines with a specific enzyme. It’s a simple natural component that can patients can take before meals, to significantly reduce this illness.

Let’s look at it in more detail below.

The DAO enzyme, a possible way to treat migraines

Foods that contain an enzyme to treat migraines

This study’s results were presented in the last international pharmaceutical conference, held in Barcelona. It was the perfect time to demonstrate the direct relationship between the DAO enzyme and migraines.

According to the chief researcher Joan Izquierdo Casas, each patient that suffered from migraines was deficient in this enzyme.

Several organizations supported this study, which lasted for a year and a half, and involved the participation of more than 100 patients who suffered from chronic and severe migraines.

The subject had between 9 and 14 migraine episodes a month. The proportion of those whom habitually suffered from migraines was followed by gender: 81% were women, and 19% were men.

In order for the study to be effective, they used a “double blind” technique, which means that neither the doctors nor the patients knew which group received the enzyme, and which group received the placebo.  This gave the conclusive results that were mentioned earlier: migraines are related to a deficiency of the DAO enzyme.

Furthermore, a hereditary component was present in some way, as this particular deficiency is transmitted from parents to their children.

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How does the DAO enzyme work to treat migraines?

This enzyme is responsible for breaking down and synthesizing a molecule called histamine, which is present in a lot of foods. The enzyme is mostly present in a greater extent in citrus fruits and dairy. Once it destroys the histamine, your body eliminates it through urine.

But, what really happens to people who suffer from migraines? By not having a sufficient amount of the DAO enzyme, they’re unable to destroy histamine, and therefore, it tends to accumulate in their blood plasma, which causes migraines and other gastrointestinal disorders.

What is treatment like?

Treatment would be very simple. Just taking one capsule of the DAO enzyme before main meals would be enough. They must take it with food because it allows them to fulfill their digestive functions. Which means they eliminate and synthesize the histamine that is present in a lot of foods.

Specialists also indicate that this enzyme is not addictive and has no adverse effects, because it’s a food. It’s a basic essential complement for digestion.

How does it work?

Ingesting exogenous DAO enzyme allows the body to reestablish the metabolism of histamine. This prevents histamine from accumulating in the small intestine. Your body must completely eliminate it after a successful digestive process.

Taking these capsules will also prevent it from entering the blood stream, which causes migraines and digestive problems.

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How to take it

You can take 1 or 2 capsules with a bit of water, twenty or thirty minutes before meals. Each dosage is equal for all adults, and they appear on the product.

Being able to get it will depend on where you live; you can find it in health stores or pharmacies.  It’s essentially a basic dietary supplement to promote digestion and eliminate histamine.

Special indications

  • Does not contain lactose or gluten
  • Appropriate for diabetics
  • It’s not a medication. Although this is a natural treatment, as with any other remedy, it’s wise to consult with your doctor for any possible side effects.

Ku, M., Silverman, B., Prifti, N., Ying, W., Persaud, Y., & Schneider, A. (2006). Prevalence of migraine headaches in patients with allergic rhinitis. Annals of Allergy, Asthma and Immunology.

Izquierdo-Casas, J., Comas-Basté, O., Latorre-Moratalla, M. L., Lorente-Gascón, M., Duelo, A., Soler-Singla, L., & Vidal-Carou, M. C. (2019). Diamine oxidase (DAO) supplement reduces headache in episodic migraine patients with DAO deficiency: A randomized double-blind trial. Clinical Nutrition.