Methylphenidate: What Is it and What’s it Used For?
Methylphenidate is a drug medical professionals indicate for the treatment of ADHD, or attention-deficit/hyperactivity disorder. Also, they prescribe it to treat postural orthostatic tachycardia syndrome and narcolepsy. However, medical professionals can also prescribe it to treat cases of fatigue and depression that are resistant to standard treatments.
The history of methylphenidate
The use of stimulants for the symptomatic treatment of narcolepsy dates back to the 30s when doctors began to prescribe ephedrine and amphetamine. Later on, thanks to clinical research, experts observed significant progress in hyperactive children who had taken amphetamines, specifically Benzedrine.
In 1944, during World War II, experts synthesized methylphenidate for the first time. During the war, many experts experimented with chemical variants of amphetamine in the search for molecules with similar properties but with fewer or milder side effects. Then, the methylphenidate patent came out in 1954. The action of this drug on the human body had, concerning other drugs of its class, fewer neuro-vegetative side effects.
Uses of methylphenidate
This drug belongs to a class of compounds with a piperidine structure. It increases the brain levels of dopamine and norepinephrine due to its ability to inhibit the reuptake of respective monoamine transporters.
Methylphenidate has a similar structure to amphetamine. However, it isn’t neurotoxic. Thus, it doesn’t have the same effects. Below, we’ll talk more about the disorders this drug is indicated for.
Attention-deficit/hyperactivity disorder (ADHD)
ADHD is a neurobiological disease that manifests in childhood. As of yet, it’s exact cause is unknown.
Attention-deficit/hyperactivity disorder is a neurobiological disorder that originates in childhood. It affects more than 5% of children in the world. Currently, experts don’t know the exact causes of the development of the condition. Nevertheless, they’re evaluating the possibility that it’s a combination of various risk factors that act together.
However, although the exact causes aren’t known, experts concluded that genetic and environmental factors have a big influence on its development. Also, attention-deficit/hyperactivity disorder has a 76% chance of being inherited.
On the other hand, as to the characteristic symptoms of this condition, we can mention three core symptoms:
For these symptoms to be associated with ADHD, they have to meet certain conditions:
- They must manifest no later than age seven.
- The symptoms must maintain over time, for at least six months.
- They should affect two or more aspects of the child’s life.
- The symptoms have to have a significant impact, deteriorating the child’s performance significantly.
Postural orthostatic tachycardia syndrome
This syndrome is characterized by dizziness or feeling faint. It manifests when the autonomous nervous system doesn’t work properly.
Postural orthostatic tachycardia syndrome causes the blood vessels to not constrict enough to ensure adequate blood supply to the brain. Thus, to try to maintain an adequate blood supply for proper brain functioning, the autonomic nervous system causes the heart to beat more and causes tachycardia.
This disease, which can be treated with methylphenidate, can occur after a viral infection or an injury. However, it’s very difficult to know if one of these circumstances is the underlying cause of this condition. Currently, experts are researching to better understand the cause of postural orthostatic tachycardia syndrome.
Medical professionals prescribe methylphenidate to patients with narcolepsy. This disorder causes extreme daytime sleepiness and involuntary sleep episodes.
People with narcolepsy often have difficulty staying awake for long periods, regardless of the circumstances.
Just as the other two conditions we explained above, experts still don’t know the specific cause of narcolepsy. However, patients with this disorder tend to have low hypocretin levels. This is a substance in the brain that helps regulate sleep-wake cycles.
You should also read: 8 Easy Ways to Fight Sleep Disorders
Methylphenidate is a prescription drug mainly used to treat attention-deficit/hyperactivity disorder. However, medical professionals also prescribe it to treat other diseases, namely the ones we discussed above.
You must follow your doctor and pharmacist’s recommendations, as it’s a drug that has serious adverse effects. Also, misusing it could have serious health consequences.It might interest you...