Manidipine as Treatment for High Blood Pressure

Doctors often prescribe manidipine as a treatment for hypertension and patients must adhere to their instructions. Usually, they initially recommend 10 mg a day; then, after 2-4 weeks, a person may increase the dose to 20 mg once a day if they didn't attain the desired effect.
Manidipine as Treatment for High Blood Pressure

Last update: 03 December, 2020

Manidipine is a treatment for high blood pressure. It belongs to the group of drugs referred to as calcium channel blockers. Their mechanism of action is to block these channels in order to relax the vascular smooth muscle and thus reduce vascular resistance.

In this way, manidipine promotes vasodilation and thus a reduction in essential blood pressure. This drug is recommended for the treatment of mild to moderate hypertension.

What’s hypertension?

Measuring blood pressure.

High blood pressure is a systolic blood pressure of 140 mm Hg or higher and a diastolic blood pressure of 90 mm Hg or higher.

However, one must differentiate between essential and secondary high blood pressure. Secondary hypertension is that which occurs as a result of organic diseases, usually renal or endocrinal.

Arterial hypertension is currently one of the most prevalent diseases in the developed world. Many consider it a cardiovascular risk factor. This is because it’s a frequent cause of:

  • Heart failure
  • Renal diseases
  • Brain diseases
  • Ocular problems

Before taking manidipine

You shouldn’t take manidipine if you’re allergic to it or other calcium channel blockers. Also, don’t take this medicine if you have severe kidney disease, heart problems, unstable angina, or liver disease.

Manidipine isn’t appropriate for anyone under 18 years old.


A person taking a manidipine pill.

Before starting treatment with manidipine, your doctor will ask if you have any heart problems. You must also tell your doctor if you’re pregnant, or if you might be, or if you’re trying to be. Also, inform them if you’re currently breastfeeding, as manidipine isn’t appropriate under any of these conditions.

It’s particularly important for your doctor to know if you’re taking any of the following medications:

  • Diuretics and beta-blockers because these medications can increase the effect of manidipine
  • Digoxin, a medication used in the treatment of heart disorders
  • Other medications such as cimetidine, antibiotics like clarithromycin and erythromycin, antifungal medications such as itraconazole and ketoconazole, and amiodarone and quinidine, both antiarrhythmics

Your doctor may prescribe another antihypertensive in these cases or just adjust the dose of both manidipine and the other medication. Also, keep in mind that alcohol consumption can enhance the effect of this drug.

How to take manidipine

You must follow your doctor’s instructions when they prescribe manidipine. Usually, the initial dose is 10 mg a day and if the desired decrease hasn’t been achieved after 2-4 weeks, they may increase the dose to 20 mg once a day.

Similarly, they may reduce the dose if the patient is older or has a kidney or liver condition.

Don’t take this medication in the morning after breakfast but take it at the same time every day. Also, don’t take a double dose if you miss one. Instead, take the next one according to your doctor’s prescription.

Possible side effects

A person holding three manidipine capsules.

Manidipine can produce side effects but most won’t affect everyone and are usually mild and temporary.

There are, however, some serious ones that require medical attention. One can classify them as follows depending on their frequency:

  • Frequent side effects such as fluid retention can cause edema, hot flashes, dizziness, headache, and palpitations.
  • Rare side effects such as tingling, increased heart rate, hypotension, respiratory distress, dry mouth, nausea, vomiting, skin rash, inflammation, and itching. In addition, transitory alterations may occur in lab tests.
  • Rare side effects include irritability, skin redness, itching, stomach and abdominal pain, drowsiness, chest pain, diarrhea, decreased appetite, and abnormal blood test results.
  • Unusual side effects include myocardial infarction and there may be an increase in the frequency, duration, or severity of these attacks in patients with pre-existing angina.


Based on the available studies of manidipine versus other hypertension drugs, the former shows a similar degree of effectiveness without significant effects on heart rate.

Thanks for reading.

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  • Rimoldi, S. F., Scherrer, U., & Messerli, F. H. (2014). Hipertensión arterial secundaria. European Heart Journal.

  • Marin, M. (2010). Hipertension Arterial De Causa Secundaria. Hipertensión Arterial – Sociedad Argentina de Cardiología.

  • Buset Ríos, N., Rodríguez Esparragón, F., & Rodríguez Pérez, J. C. (2009). Propiedades cardiometabólicas del manidipino: ¿más allá de la reducción de la presión arterial? Nefrologia.